SPICA 2018

17th International Symposium on Preparative and Industrial Chromatography and Allied Techniques

 Darmstadt, Germany    October 7-10, 2018

Programme


13:00

Registration (until 19:00)

Foyer Hall Spectrum A

Workshops (subject to separate registration)

14:00

Start of sessions

Workshop 1
Workshop 2
Workshop 1
14:00
Multicolumn Processes: From Historical SMB to the Latest Advances in the Purification of Biomolecules
José Paulo MOTA
UNIVERSIDADE NOVA DE LISBOA, Caparica, Portugal
Olivier DAPREMONT
AMPAC FINE CHEMICALS, Rancho Cordova, United States
Workshop 2
From Development to Commercial Scale: How to Integrate QbD Tools and Data Analysis
Alessandro BUTTE
ETH ZURICH, Zurich, Switzerland
15:30

Coffee Break

16:00

Start of sessions

Workshop 3
Workshop 4
Workshop 3
16:00
Preparative HPLC of Peptides and Small Molecules: Phase Screening, Method Optimisation, Process Design
Michael SCHULTE
MERCK KGAA, Darmstadt, Germany
Jochen STRUBE
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
Ulrich EMDE
MERCK KGAA, Darmstadt, Germany
Workshop 4
Real Time Monitoring and Control of Process Chromatography
Alois JUNGBAUER
UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria
17:45

Opening Ceremony

Hall Spectrum B+C

18:00

KL01 - A New View on Surface Diffusion from Molecular Dynamics Simulations of Solute Mobility at Chromatographic Interfaces

Ulrich TALLAREK
PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany

18:45

Welcome Reception

Hall Spectrum A

20:00

End of the Day

08:00

Registration

Foyer Hall Spectrum A

08:45

Welcome

Session 1: Joachim Kinkel Symposium

Hall Spectrum B+C

Session Chair

Michael SCHULTE
MERCK KGAA, Darmstadt, Germany

09:00

Opening Remarks

09:10

OC01 - Measurement, Description and Consistent Application of Adsorption Equilibria

Andreas SEIDEL-MORGENSTERN
MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany

09:30

OC02 - How Continuous Chromatography Moved from Craftwork to Industry. A Tribute to Passion and Creativity.


AM-PHARMA

09:50

OC03 - Modified Inorganic Sorbents for the Fast and Efficient Separation of Biomolecules

Benjamin PETERS
MERCK KGAA, Darmstadt, Germany

10:10

OC04 - Centrifugal Partition Chromatography: new Possibilities with a Liquid Stationary Phase

Mirjana MINCEVA
TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany

10:30

Coffee Break sponsored by MERCK

Hall Spectrum A

Session 2: Chromatographic Media

Hall Spectrum B+C

Session Chair

Tuomo SAINIO
LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland

11:00

KL02 - On the Advantage of Ordered Chromatographic Media

Gert DESMET
VRIJE UNIVERSITEIT BRUSSEL (VUB), Brussels, Belgium

11:40

OC05 - Interplay of Mathematics and Physics of 3D Printing for Chromatography

Carlos GRANDE
SINTEF, Oslo, Norway

12:00

OC06 - New Adsorptive Technology and its Use Within Purification Platform for Antibody-Process Related Impurities Removal

Fabien ROUSSET
CHIRAL TECHNOLOGIES, Illkirch, France

12:20

OC07 - A New Cation Exchange Resin Designed for the Removal of Monoclonal Antibody Aggregates Using Flow-Through Frontal Chromatography

Romas SKUDAS
MERCK KGAA, Darmstadt, Germany

12:40

Lunch and Exhibition (until 14:00)

Hall Spectrum A

13:00

Start of sessions

Vendor Seminar 1
Vendor Seminar 2
Vendor Seminar 1
13:00
Agilent Technologies
The New Benchmark for Preparative LC Workflows - Pathways to Achieve Exceptional Accuracy and Flexibility (13:00-14:00)
Vendor Seminar 2
Osaka Soda Co., Ltd.
Taming the Devil (Advances in the Understanding of CIP in RP HPLC Processes) (13:00-14:00)

Session 3: Theory and Simulations

Hall Spectrum B+C

Session Chair

Andreas SEIDEL-MORGENSTERN
MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany

14:00

KL03 - Computational Fluid Dynamics to Understand Process Chromatography

Alois JUNGBAUER
UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria

14:40

OC08 - When Adsorption Models or Intuition Fail at Describing Ion-Exchange Chromatography

Hector OSUNA
YPSO-FACTO, Nancy, France

15:00

OC09 - Improvement of Multicapillary Packing Efficiency by Diffusional Bridging: A Theoretical and Dynamic Simulation Study

Francois PARMENTIER
SEPARATIVE, Solaize, France

15:20

OC10 - Chromatographic Separations with Focusing of Both the Weak and the Strong Component

Tuomo SAINIO
LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland

15:40

Coffee Break sponsored by AMPAC FINE CHEMICALS

Hall Spectrum A

Session 4: Continuous Chromatography

Hall Spectrum B+C

Session Chair

Olivier DAPREMONT
AMPAC FINE CHEMICALS, Rancho Cordova, United States

16:10

OC11 - Design and Optimization of a Continuous Separation of Tartronic and Glyceric Acids by Simulated Moving Bed

Lucas COELHO
UNIVERSITY OF PORTO, Porto, Portugal


&
FEDERAL UNIVERSITY OF PERNAMBUCO, Recife, Brazil

16:30

OC12 - Strategies for the Global Multicomponent Separation of Nadolol Stereoisomers by Chiral and Achiral Fixed-Bed and Simulated Moving Bed Chromatography

António E. RIBEIRO
POLYTECHNIC INSTITUTE OF BRAGANÇA, Braganca, Portugal

16:50

OC13 - Inexiotech - This Disruptive Technology Allows for the Resolution of Multicomponent Mixtures in a Serial Continuous Process

Alexandre MACIUK
UNIVERSITÉ PARIS-SUD, Chatenay-Malabry, France


&
FAUQUET INNOVATION, Montmagny, France

17:10

OC14 - Model Predictive Control of 4-Zone Simulated Moving Bed Chromatography for the Separation of Bicalutamide Enantiomers: Experimental Validation

Ju Weon LEE
MAX-PLANCK-INSTITUTE FOR DYNAMICS OF COMPLEX TECHINCAL SYSTEMS, Magdeburg, Germany

17:30

OC15 - Evaluation of Continuous Purification of Therapeutic Extracellular Vesicles

Mafalda MOLEIRINHO
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECHNOLOGICA, Oeiras, Portugal

17:50

Poster Session 1 & Beer Party

Hall Spectrum A

18:50

End of the Day

Session 5: Peptides and Proteins

Hall Spectrum B+C

Session Chair

José Paulo MOTA
UNIVERSIDADE NOVA DE LISBOA, Caparica, Portugal

08:30

KL04 - Synthetic Peptide Manufacturing: Downstream Challenges and Innovations

Olivier LUDEMANN-HOMBOURGER
POLYPEPTIDE LABORATORIES FRANCE, Strasbourg, France

09:10

OC16 - Hybrid Optimisation of Preparative Chromatography for a Difficult and Realistic Ternary Protein Mixture

Vivien FISCHER
UNIVERISTY COLLEGE LONDON / GLAXOSMITHKLINE, Stevenage , United Kingdom

09:30

OC17 - Scalability of Mini-Columns in Protein Chromatography

Dorota ANTOS
RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland

09:50

OC18 - Process Analysis for Preparative Protein Chromatography Using In-Line Attenuated Total Reflection Fourier Transform Infrared Spectroscopy

Adrian SANDEN
KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany

10:10

OC19 - Cost Effective Peptide Purification via ZEOsphere DRP Mixed-Mode Chromatography

Alessandro BUTTE
ETH ZURICH, Zurich, Switzerland

10:30

Coffee Break and Exhibition

Hall Spectrum A

Session 6: Purification of Antibodies I

Hall Spectrum B+C

Session Chair

Dorota ANTOS
RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland

11:00

OC20 - Continuous Biomanufacturing- Platform Alternatives for Antibody Production

Steffen ZOBEL-ROOS
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany

11:20

OC21 - Antibody Aggregate Removal Using Frontal Chromatography: Performance Comparison Between Column and Membrane Adsorber

Sebastian VOGG
ETH ZURICH, Zürich, Switzerland

11:40

OC22 - Continuous Conjugation of Antibodies By rMCSGP

Nicole ULMER
ETH ZURICH, Zurich, Switzerland

12:00

OC23 - Temperature Dependence of Antibody Adsorption in Protein A Affinity Chromatography

Walpurga KREPPER
UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria

12:20

Lunch Break and Exhibition (until 13:40)

Hall Spectrum A

12:40

Start of sessions

Vendor Seminar 3
Vendor Seminar 4
Vendor Seminar 3
12:40
Kromasil-AkzoNobel PPC
Method Development and Purification of Biotherapeutics including Peptides and Oligonucleotides (12:40-13:40)
Vendor Seminar 4
Tosoh Bioscience GmbH
Reduce your Downstream Processing Costs and Know More About your Target Molecules (12:40-13:40)
13:40

Poster Session 2

Hall Spectrum A

Session 7: Green Purification Technologies

Hall Spectrum B+C

Session Chair

Pilar FRANCO
CHIRAL TECHNOLOGIES EUROPE, Illkirch, France

14:40

KL05 - SFC-MS in Drug Discovery: The Technology Shaping Tomorrow’s Innovation

Gerard ROSSE
DART NEUROSCIENCE, San Diego, United States

15:20

OC24 - Alternative Approaches in Preparative Chromatography for Purifying Lipophilic Compounds and the Elimination of Chlorinated Solvents

Markus JUZA
CORDEN PHARMA SWITZERLAND, Liestal, Switzerland

15:40

OC25 - Studies on Robustness of SFC: Examples from Chiral and Peptide Separations

Torgny FORNSTEDT
KARLSTAD UNIVERSITY, Karlstad, Sweden

16:00

OC26 - Operating Mode Selection for Ternary Separations with Liquid-Liquid Chromatography

Raena MORLEY
TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany

16:20

Coffee Break and Exhibition

Hall Spectrum A

Session 8: Natural Products

Hall Spectrum B+C

Session Chair

Mirjana MINCEVA
TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany

16:50

KL06 - Accessing Nature’s Chemical Diversity for Drug Discovery

Philipp KRASTEL
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland

17:30

OC27 - Development of a Chromatographic Based Purification Strategy for Artemisinin from Artemisia Annua L. Extract

Fabian MESTMÄCKER
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany

17:50

OC28 - Chromatographic Recovery of Hydroxy Acids, Lignin, and Pulping Chemicals from Spent Alkaline Pulping Liquors

Jari HEINONEN
LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland

20:00

Gala Dinner

Session 9: Antibodies and Proteins II

Hall Spectrum B+C

Session Chair

Olivier LUDEMANN-HOMBOURGER
POLYPEPTIDE LABORATORIES FRANCE, Strasbourg, France

08:30

OC29 - Visualization and Quantification of Protein Bind and Elute Processes to the IEX Hydrogel of a Membrane Adsorber

Adrian LEY
SARTORIUS STEDIM BIOTECH GMBH / INSTITUTE OF PHYSICAL CHEMISTRY, GEORG-AUGUST UNIVERSITY GOETTINGEN, Goettingen, Germany

08:50

OC30 - Water on Hydrophobic Surfaces - Mechanistic Modeling of Polyethylene Glycol-Induced Protein Precipitation

Steffen GROSSHANS
KARLSRUHE INSTITUTE OF TECHNOLOGY (KIT), Karlsruhe, Germany

09:10

OC31 - Membrane Based Separation of Aqueous Two-Phase Systems for the Purification of Monoclonal Antibodies

Thomas KRUSE
SARTORIUS STEDIM BIOTECH & CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Göttingen, Germany

09:30

SPICA 2018 Poster Prizes

09:50

Coffee Break and Exhibition

Hall Spectrum A

Session 10: Process Optimization Chromatography and Case Studies

Hall Spectrum B+C

Session Chair

Jochen STRUBE
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany

10:20

KL07 - Efficient Simulation and Control of Chromatographic Processes

Achim KIENLE
OTTO VON GUERICKE UNIVERSITY MAGDEBURG, Magdeburg, Germany

11:00

OC32 - Automatic Determination of Optimum Operating Concepts and Process Variables for Multi-Component Separations

Johannes SCHMÖLDER
FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, Erlangen, Germany

11:20

OC33 - Optimization of Processes Combining Chemistry & Purification - Strategies & Case Studies

Jérome BONI
NOVASEP, Chasse-sur-Rhone, France

11:40

OC34 - Continuous Centrifugal Partition Chromatography: Using a Mass Transfer Model for Process Optimization and Various Mode Comparison

Luc MARCHAL
UNIVERSITÉ DE NANTES, Saint Nazaire, France

12:00

OC35 - Model-Based Quality by Design: Challenges, Pitfalls and Best Practices

Maria CASALS PERAVAREZ
GOSILICO, Karlsruhe, Germany

12:20

Kinkel Symposium Award

12:25

Closing Remarks